Hepatitis C-related cirrhosis will be a marginal cause of hospital admissions in the near future.

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Complications of liver cirrhosis (LC) are the main cause of hospital admissions in liver units. In areas where hepatitis C virus (HCV) is highly prevalent, most of these admissions are […]

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RNA editing mediates the functional switch of COPA in a novel mechanism of hepatocarcinogenesis.

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RNA editing introduces nucleotide changes in RNA sequences. Recent studies have reported aberrant adenosine-to-inosine RNA editing is implicated in cancers. Until now, very few functionally important protein-recoding editing targets have […]

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Inhibition of IRAK4 kinase activity improves ethanol-induced liver injury in mice.

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Alcohol-related liver disease (ALD) is a major cause of chronic liver disease worldwide with limited therapeutic options. Interleukin-1 Receptor Associated Kinase 4 (IRAK4), the master kinase of TLRs/IL-1R-mediated signaling activation, […]

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EXTRACELLULAR VESICLES AS BIOMARKERS IN LIVER DISEASES: A CLINICIAN’S POINT OF VIEW.

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Extracellular vesicles are membrane-bound vesicles containing proteins, lipids, RNAs and microRNAs. They can originate from both healthy and stressed cells, and provide a snapshot of the cell of origin in […]

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Sex is associated with differences in gut microbial composition and function in hepatic encephalopathy.

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Altered microbiota can affect gut-liver-brain axis in cirrhosis and hepatic encephalopathy (HE), but the impact of sex on these changes is unclear. We aimed to determine differences in fecal microbiota […]

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Next generation sequencing in the diagnosis of non-cirrhotic splanchnic vein thrombosis.

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Myeloproliferative neoplasms (MPN) are the most frequent cause of non-tumoral non-cirrhotic splanchnic vein thrombosis (NC-SVT). Diagnosis of MPN is based on blood cell count alterations, bone marrow histology and detection […]

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The PREDICT study uncovers three clinical courses in acutely decompensated cirrhosis with distinct pathophysiology.

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Acute decompensation (AD) of cirrhosis is defined by the acute development of ascites, gastrointestinal hemorrhage, hepatic encephalopathy, infection or any combination of these, requiring hospitalization. The presence of organ failure(s) […]

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Altered aryl-hydrocarbon-receptor signalling affects regulatory and effector cell immunity in autoimmune hepatitis.

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In autoimmune hepatitis (AIH) imbalance between Treg and Th17-cells has been linked to low levels of CD39, an ectoenzyme that hydrolyses ATP ultimately generating immunosuppressive adenosine. Upregulation of CD39 results […]

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Integrative molecular profiling of autoreactive CD4 T cells in autoimmune hepatitis.

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In most autoimmune disorders, crosstalk of B cells and CD4 T cells results in the accumulation of autoantibodies. In autoimmune hepatitis (AIH), the presence of anti-Soluble Liver Antigen (SLA) autoantibodies […]

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Origin, HDV genotype and persistent viremia determine outcome and treatment response in patients with chronic hepatitis Delta.

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Hepatitis delta virus (HDV) infection causes severe chronic liver disease in Hepatitis B virus (HBV) infected individuals. Factors associated with poor prognosis are largely unknown.The French National Reference Centre for […]

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Repeated FIB-4 measurements can help identify individuals at risk of severe liver disease.

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It is unclear as to whether the identification of individuals at risk of cirrhosis using noninvasive tests can be improved by repeated measurements.Data were derived from the population-based Swedish AMORIS […]

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Personalized surveillance for hepatocellular carcinoma in cirrhosis – using machine learning adapted to HCV status.

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To develop algorithms based on machine learning predictive approaches to refine individualized predictions of hepatocellular carcinoma (HCC) risk according to HCV eradication in patients with cirrhosis included in the French […]

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Suboptimal reliability of liver biopsy evaluation has implications for randomized clinical trials.

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Liver biopsies are a critical component of pivotal studies in nonalcoholic steatohepatitis (NASH) constituting main inclusion criteria, risk stratification factors and endpoints. We evaluated the reliability of NASH Clinical Research […]

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Dampened VEPH1 activates mTORC1 signaling by weakening the TSC1/TSC2 association in hepatocellular carcinoma.

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Abnormal activation of mTORC1 signaling occurs at high frequency in hepatocellular carcinoma (HCC). However, the underlying mechanisms remain elusive. In this study, we identified ventricular zone expressed pleckstrin homology domain-containing […]

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Reduced mitochondrial resilience enables non-canonical induction of apoptosis after TNF receptor signaling in virus-infected hepatocytes.

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Selective elimination of virus-infected hepatocytes occurs through virus-specific CD8 T-cells recognizing peptide-loaded MHC molecules. Here, we report that virus-infected hepatocytes are also selectively eliminated through a cell-autonomous mechanism.We generated recombinant […]

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Multi-generational maternal obesity increases the incidence of HCC in offspring via miR-27a-3p.

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The global obesity epidemic is threatening human health. How maternal obesity affects the incidence of offspring hepatocellular carcinoma (HCC) remains unknown. We investigated this association and the underlying mechanism.Diethylnitrosamine (DEN) […]

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Determinants of mortality in patients with cirrhosis and uncontrolled variceal bleeding.

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Failure to control oesophago-gastric variceal bleeding (OGVB) and acute-on-chronic liver failure (ACLF) are both important prognostic factors in liver cirrhosis. The aims of this study were to determine whether ACLF […]

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Similar risk of hepatocellular carcinoma during long-term entecavir or tenofovir therapy in Caucasian patients with chronic hepatitis B.

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The incidence of hepatocellular carcinoma (HCC) was recently reported to be lower in Asian chronic hepatitis B (CHB) patients treated with tenofovir disoproxil fumarate (TDF) than entecavir (ETV), but this […]

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Beta-amyloid deposition around hepatic bile ducts is a novel pathobiological and diagnostic feature of biliary atresia.

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Biliary atresia (BA) is a poorly understood deadly liver disease, often diagnosed late, is incurable and frequently requires liver transplantation. In this study, we aim to investigate the underlying pathomechanisms […]

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Blocking integrin α4β7-mediated CD4 T cell recruitment to the intestine and liver protects mice from western diet-induced non-alcoholic steatohepatitis.

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The heterodimeric integrin receptor α4β7 regulates CD4 T cell recruitment to inflamed tissues, but its role in the pathogenesis of nonalcoholic steatohepatitis (NASH) is unknown. Here we examined the role […]

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Clinical outcome and hemodynamic changes following HCV eradication with oral antiviral therapy in patients with clinically significant portal hypertension.

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Clinically significant portal hypertension (CSPH, HVPG≥10mmHg) persists 24 weeks after sustained virological response (SVR) in up to 78% of patients with HCV-related cirrhosis treated with direct acting antivirals. These patients […]

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Tissue engineering of the biliary tract and modelling of cholestatic disorders.

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Our insight into the pathogenesis of cholestatic liver disease remains limited, partly due to challenges in capturing the multitude of factors contributing to the disease pathogenesis in vitro. Tissue engineering […]

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Single-cell genomics and spatial transcriptomics: discovery of novel cell states and cellular interactions in liver physiology and disease biology.

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Transcriptome analysis allows the study of gene expression of human tissues and it is a valuable tool to characterize liver function, gene expression changes during liver disease, identify prognostic markers […]

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Model for end-stage liver disease-sodium underestimates 90-day mortality risk in patients with acute-on-chronic liver failuare.

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The Model for End-stage Liver Disease with sodium correction (MELD-Na) is designed to prioritize liver transplantation (LT). MELD-Na predicts 90-day mortality in cirrhosis but it is unclear whether MELD-Na captures […]

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Non-alcoholic fatty liver disease in pregnancy is associated with adverse maternal and perinatal outcomes.

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Non-alcoholic fatty liver disease (NAFLD) is rising in young adults, with potential implications for reproductive-aged women. Whether NAFLD during pregnancy confers more serious risks for maternal or perinatal health is […]

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