The sleep apnea-specific hypoxic burden predicts incident heart failure.

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Heart failure (HF) is a leading cause of morbidity and mortality and while linked to sleep apnea, it is unclear which physiological stressors most strongly associate with incident disease. Here […]

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Continuous Positive Airway Pressure Treatment, Glycemia, and Diabetes Risk in Obstructive Sleep Apnea and Comorbid Cardiovascular Disease.

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Despite evidence of a relationship among obstructive sleep apnea (OSA), metabolic dysregulation, and diabetes, it is uncertain whether OSA treatment can improve metabolic parameters. We sought to determine effects of […]

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Efficacy of continuous positive airway pressure (CPAP) for improvements in sleepiness, cognition, mood and quality of life in elderly patients with obstructive sleep apnea: Systematic review and meta-analysis of randomized controlled trials.

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Obstructive sleep apnea (OSA) is commonly found in the elderly population (≥ 65 years old), and continuous positive airway pressure (CPAP) improves sleepiness, health-related quality of life (HRQoL) in the […]

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The Effect of Venlafaxine on Apnea Hypopnea Index in Patients with Sleep Apnea – a Randomized, Double-Blind Crossover Study.

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One of the key mechanisms underlying obstructive sleep apnea (OSA) is a reduced pharyngeal muscle tone during sleep. Recent data suggest that pharmacological augmentation of central serotonergic/adrenergic tone increases pharyngeal […]

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Undiagnosed Obstructive Sleep Apnea May Significantly Impact Outcomes in Adults Admitted for COPD in an Inner-City Hospital.

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Chronic Obstructive Pulmonary Disease (COPD) is the second most common cause of hospital admission in the United States. Obstructive sleep apnea (OSA) is a highly prevalent and underdiagnosed condition which […]

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Relation of Age to Survival in Patients with Obstructive Sleep Apnea who Develop an Acute Coronary Event (from the National Inpatient Sample).

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This study was undertaken to investigate whether obstructive sleep apnea (OSA) produces a survival advantage in acute coronary syndrome (ACS), and to evaluate the mechanism of any benefit, including the […]

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Obstructive sleep apnea and neurocognitive impairment in children with congenital heart disease.

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Children with congenital heart disease (CHD) have an increased risk of neurocognitive impairment. No prior studies have evaluated the role of obstructive sleep apnea (OSA), which is associated with neurocognitive […]

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Update on Persistent Excessive Daytime Sleepiness in Obstructive Sleep Apnea.

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Obstructive sleep apnea (OSA) is a highly prevalent sleep disorder and subjective excessive daytime sleepiness (EDS) is the cardinal symptom for which many individuals seek medical advice. Positive airway pressure […]

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Palatal Sensory Function Worsens in Untreated Snorers but not in CPAP-treated Sleep Apnea Patients, indicating Vibration-induced Nervous Lesions.

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snoring per se may damage all upper airway neurons over time, thereby causing progression to manifest sleep apnea. To test this, non-snoring subjects, untreated snorers and CPAP-treated patients underwent repeated […]

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Effects of the Combination of Atomoxetine and Oxybutynin on Obstructive Sleep Apnea Endotypic Traits.

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We recently showed that the administration of the combination of the noradrenergic drug atomoxetine plus the antimuscarinic oxybutynin (ato-oxy) before sleep greatly reduced obstructive sleep apnea (OSA) severity, likely by […]

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Update on Apneas of Heart Failure with Reduced Ejection Fraction: Emphasis on the Physiology of Treatment Part 2: Central Sleep Apnea.

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Central sleep apnea/Hunter-Cheyne-Stokes Breathing (CSA/HCSB), is prevalent in patients with heart failure with reduced ejection fraction (HFrEF). The acute pathobiological consequences of CSA/HSCB eventually lead to sustained sympathetic over-activity, repeated […]

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Effects of suboptimal adherence of CPAP-therapy on symptoms of obstructive sleep apnea: a randomised, double-blind, controlled trial.

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Continuous positive airway pressure (CPAP) is currently the treatment of choice for sleepiness in patients with obstructive sleep apnea (OSA), however, adherence is often thought to be suboptimal. We investigated […]

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Prevalence of obstructive sleep apnea in Alzheimer’s disease patients.

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To assess the prevalence of obstructive sleep apnea (OSA) in patients with mild-moderate Alzheimer’s Disease (AD) and to evaluate cognitive characteristics according to the severity of OSA.Patients with mild-moderate AD, […]

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Responsiveness of Patient Reported Outcomes to Treatment among Patients with Type 2 Diabetes Mellitus and Obstructive Sleep Apnea.

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The Patient Reported Outcomes Information System (PROMIS) includes two instruments to quantify sleep symptoms (sleep disturbance, SDA; sleep-related impairment, SRI) in diverse populations across a wide symptom spectrum. However, the […]

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Obstructive Sleep Apnea in Acromegaly and the Effect of Treatment: A Systematic Review and Meta-Analysis.

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Obstructive Sleep Apnea (OSA) is a common disorder characterized by upper airway collapse requiring nocturnal ventilatory assistance. Multiple studies have investigated the relationship between acromegaly and OSA reporting discordant results.To […]

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Circulating Plasma Exosomes in Obstructive Sleep Apnea and Reverse-Dipping Blood Pressure.

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Obstructive Sleep Apnea (OSA) increases the risk of abnormal non-dipping 24-hour blood pressure profile, an independent risk factor for cardiovascular disease (CVD). We examined differential exosomal miRNA expression in untreated […]

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The course of obstructive sleep apnea syndrome in patients with acromegaly during treatment.

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Abstract: Obstructive sleep apnea syndrome (OSAS) is common in active acromegaly and negatively influences quality of life, morbidity and mortality. This prospective study with three predetermined timepoints and a standardized […]

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Utility of Pacemaker With Sleep Apnea Monitor to Predict Left Ventricular Overload and Acute Decompensated Heart Failure.

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Abstract: Pacemakers with sleep apnea monitor (SAM) provide an easy tool to assess obstructive sleep apnea over long periods of time. The link between respiratory disturbances at night and the […]

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Utility of Pacemaker With Sleep Apnea Monitor to Predict Left Ventricular Overload and Acute Decompensated Heart Failure.

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Abstract: Pacemakers with sleep apnea monitor (SAM) provide an easy tool to assess obstructive sleep apnea over long periods of time. The link between respiratory disturbances at night and the […]

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Bilateral Hypoglossal Nerve Stimulation for Treatment of Adult Obstructive Sleep Apnea.

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Abstract: Hypoglossal Nerve Stimulation (HNS) decreases Obstructive Sleep Apnea (OSA) severity via genioglossus muscle activation and decreased upper airway collapsibility. This study assessed the safety and effectiveness at 6 months post-implantation […]

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Bilateral Hypoglossal Nerve Stimulation for Treatment of Adult Obstructive Sleep Apnea.

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Abstract: Hypoglossal Nerve Stimulation (HNS) decreases Obstructive Sleep Apnea (OSA) severity via genioglossus muscle activation and decreased upper airway collapsibility. This study assessed the safety and effectiveness at 6 months post-implantation […]

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Allergic Rhinitis and Obstructive Sleep Apnea in Children Residing at High-Altitude.

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Abstract: Obstructive sleep apnea (OSA) affects 2-4 % of the pediatric population; allergic rhinitis (AR) has been identified as a risk factor in sleep-disordered-breathing, but no studies evaluating such association […]

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Sleep Apnea and Chronic Kidney Disease – A State of the Art Review.

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Abstract: Patients with chronic kidney disease have increased morbidity and mortality, mainly due to cardiovascular disease. Compared to the general population, patients with chronic kidney disease have an increased prevalence […]

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Phenotypic sub-types of obstructive sleep apnea: a challenge and opportunity for precision medicine.

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Abstract: Current strategies for management of obstructive sleep apnea (OSA) reflect a one-size-fits-all approach. Diagnosis and severity of OSA are based on the apnea hypopnea index and treatment initiated with […]

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Polysomnography and Treatment-Related Outcomes of Childhood Sleep Apnea.

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Abstract: Polysomnography is central to the diagnosis and management of childhood obstructive sleep apnea (OSA). However, it is not known whether the treatment-related outcomes of OSA are causally associated with […]

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Mutations in MAGEL2 and L1CAM are associated with congenital hypopituitarism and arthrogryposis.

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Abstract: Congenital hypopituitarism (CH) is rarely observed in combination with severe joint contractures (arthrogryposis). Schaaf-Yang syndrome (SHFYNG) phenotypically overlaps with Prader-Willi syndrome, with patients also manifesting arthrogryposis. L1 syndrome: a […]

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Minimally Invasive Hysterectomy and Bariatric Surgery to Improve Endometrial Cancer Survivorship.

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Abstract: Surgery is curative for the majority of early-stage endometrial cancers. Postoperatively, patients are actually at much higher risk of mortality from obesity-related comorbidities unless they have sustained weight loss.A […]

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