COVID-19 and its implications for thrombosis and anticoagulation.

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The SARS-CoV-2 coronavirus (COVID-19) induced infection can be associated with a coagulopathy, findings consistent with infection induced inflammatory changes as observed in patients with disseminated intravascular coagulopathy (DIC). The lack […]

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COVID-19 Coagulopathy in Caucasian patients.

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Although the pathophysiology underlying severe COVID-19 remains poorly understood, accumulating data suggest that a lung-centric coagulopathy may play an important role. Elevated D-dimer levels which correlated inversely with overall survival […]

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Alternative assays to dRVVT and aPTT for lupus anticoagulant detection.

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Lupus anticoagulants (LA) are heterogeneous antibodies and no single assay will detect every LA. Consequently, testing is commonly undertaken with both dilute Russell’s viper venom time (dRVVT) and LA-responsive activated […]

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Changes in Blood Coagulation in Patients with Severe Coronavirus Disease 2019 (COVID-19): a Meta-Analysis.

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Coronavirus disease 2019 (COVID-19) is widely spread and poses a critical threat to global health (Zhang et al). Prominent changes in coagulation function in severe patients of COVID-19 have been […]

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Thromboembolic risk and anticoagulant therapy in COVID-19 patients: Emerging evidence and call for action.

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Emerging evidence shows that severe coronavirus disease 2019 (COVID-19) can be complicated with coagulopathy namely disseminated intravascular coagulation, which has a rather pro-thrombotic character with high risk of venous thromboembolism. […]

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Platelet protein S limits venous but not arterial thrombosis propensity by controlling coagulation in the thrombus.

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Anticoagulant protein S (PS) in platelets (PSplt) resembles plasma PS and is released upon platelet activation; but its role in thrombosis has not been elucidated. Here we report that inactivation […]

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Anticoagulation with or without Clopidogrel after Transcatheter Aortic-Valve Implantation.

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The roles of anticoagulation alone or with an antiplatelet agent after transcatheter aortic-valve implantation (TAVI) have not been well studied.We performed a randomized trial of clopidogrel in patients undergoing TAVI […]

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Diagnosis of suspected recurrent ipsilateral deep vein thrombosis with magnetic resonance direct thrombus imaging.

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The diagnosis of recurrent ipsilateral deep vein thrombosis (DVT) is challenging because persistent intravascular abnormalities after previous DVT often hinder a diagnosis by compression ultrasonography. Magnetic resonance direct thrombus imaging […]

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The role of type 1 interferons in Gram-negative bacteria-induced coagulation.

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Bacterial infection not only stimulates innate immune responses but also activates the coagulation cascades. Over-activation of the coagulation system in bacterial sepsis leads to disseminated intravascular coagulation (DIC), a life-threatening […]

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Seronegative antiphospholipid syndrome: refining the value of non-criteria antibodies for the diagnosis and clinical management.

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Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by arterial and venous thrombotic manifestations and/or pregnancy-related complications in patients with persistently high antiphospholipid antibodies (aPL), the most common being […]

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Alternative activation of human macrophages enhances tissue factor expression and production of extracellular vesicles.

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Macrophages are versatile cells that can be polarized by the tissue environment to fulfill required needs. Proinflammatory polarization is associated with increased tissue degradation and propagation of inflammation whereas alternative […]

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CRISPR/Cas9-mediated knockin of human factor IX into swine factor IX locus effectively alleviates bleeding in hemophilia B pigs.

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Hemophilia B is an X-linked recessive bleeding disorder caused by abnormalities in the coagulation factor IX gene. Without prophylactic treatment, patients experience frequent spontaneous bleeding episodes. Well-characterized animal models are […]

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Protein C activator AB002 rapidly interrupts thrombus development in baboons and appears safe in a first-in-human trial.

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While thrombin is a key enzyme in the coagulation cascade and is required for both normal hemostasis and pathologic thrombogenesis, it also participates in its own negative feedback via activation […]

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Thrombin-mediated activation of PAR-1 contributes to microvascular stasis in mouse models of sickle cell disease.

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Vaso-occlusive crisis (VOC) is the primary cause of morbidity and hospitalization in sickle cell disease (SCD). However, only three therapies (hydroxyurea, L-glutamine, and crizanlizumab) are currently approved in SCD. These […]

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Red Blood Cell Microvesicles Activate The Contact System Leading To Factor IX Activation Via Two Independent Pathways.

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Storage lesion-induced red cell-derived microvesicles (RBC-MVs) propagate coagulation by supporting the assembly of the prothrombinase complex. It has also been reported that RBC-MVs initiate coagulation via the intrinsic pathway. To […]

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Acetylsalicylic acid (ASA) inhibits intravascular coagulation during S. aureus-induced sepsis in mice.

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Anti-platelet therapies have been proposed for the treatment of sepsis, a syndrome resulting from a dysregulated immune response and inappropriate activation of coagulation. Acetylsalicylic acid (ASA) may serve as a […]

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How I assess and manage the risk of bleeding during treatment of patients with venous thromboembolism.

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For patients with venous thromboembolism (VTE), prediction of bleeding is relevant throughout the course of treatment, although the means and goal of this prediction differ between the subsequent stages of […]

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Treatment of unusual thrombotic manifestations.

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Venous thrombosis rarely occurs at unusual sites such as cerebral, splanchnic, upper extremity, renal, ovarian or retinal veins. Clinical features, symptoms and risk factors of rare thrombotic manifestations are heterogeneous […]

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Treatment of venous thromboembolism in pediatric patients.

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Venous thromboembolism (VTE) is rare in healthy children,but an increasing problem in children with underlying medical conditions. Pediatric VTE encompasses a highly heterogenous population, with variation in age, thrombosis location […]

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Novel Antithrombotic Strategies for Treatment of Venous Thromboembolism.

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Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE), is the third most common cause of vascular death after heart attack and stroke. Anticoagulation therapy is […]

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ACUTE TREATMENT OF VENOUS THROMBOEMBOLISM.

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All patients with venous thromboembolism should receive anticoagulant treatment in the absence of absolute contraindications. Initial anticoagulant treatment is crucial to reduce mortality, prevent early recurrences and improve long-term outcome. […]

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Complement activity and complement regulatory gene mutations are associated with thrombosis in APS and CAPS.

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The antiphospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy morbidity in the presence of antiphospholipid antibodies including anti-beta-2-glycoprotein-I (anti-β2GPI) that are considered central to APS pathogenesis. Based on animal […]

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Safety of dabigatran etexilate for the secondary prevention of venous thromboembolism in children.

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This open-label, single-arm, prospective cohort trial is the first phase 3 safety study to describe outcomes in children treated with dabigatran etexilate for secondary venous thromboembolism (VTE) prevention. Eligible children […]

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From Budd-Chiari syndrome to acquired von Willebrand syndrome: thrombosis and bleeding complications in the myeloproliferative neoplasms.

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Thrombotic and hemorrhagic complications are prevalent in patients with essential thrombocythemia, polycythemia vera, and myelofibrosis. Given the impact on morbidity and mortality, reducing the risk of thrombosis and/or hemorrhage is […]

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