The Effects of Human Prothrombin Complex Concentrate on Hemorrhagic Shock Induced Lung Injury in Rats: Implications for Testing Human Blood Products in Rodents.

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Hemorrhagic shock (HS) and trauma can result in an endotheliopathy of trauma, characterized by endothelial compromise, inflammation and aberrant coagulation. Kcentra, a pro-thrombin concentrate, has been demonstrated to mitigate pulmonary […]

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Deaths following withdrawal of life sustaining therapy: opportunities for quality improvement?

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Mortality is an important trauma center outcome. With many patients initially surviving catastrophic injuries and a growing proportion of geriatric patients, many deaths might occur following withdrawal of life sustaining […]

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Isolated Rib Cage Fractures in the Elderly: Do All Patients Belong to the Intensive Care Unit? A retrospective nationwide analysis.

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Western Trauma Association guidelines recommend admitting patients≥65 years old with>2 rib fractures diagnosed by chest radiograph (CXR) to the intensive care unit (ICU). Increased use of computed tomography (CT) has […]

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COVID-19 pandemic and admission rates for and management of acute coronary syndromes in England.

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Several countries affected by the COVID-19 pandemic have reported a substantial drop in the number of patients attending the emergency department with acute coronary syndromes and a reduced number of […]

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Impact of the Four-Hour Rule policy on emergency medical services delays in Australian EDs: a longitudinal cohort study.

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Delayed handover of emergency medical services (EMS) patients to EDs is a major issue with hospital crowding considered a primary cause. We explore the impact of the 4-hour rule (the […]

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Superior primary fascial closure rate and lower mortality after open abdomen using negative pressure wound therapy with continuous fascial traction.

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Open abdomen (OA) is a useful option for treatment strategy in many acute abdominal catastrophes. A number of temporary abdominal closure (TAC) methods are used with limited number of comparative […]

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Perspectives of emergency department attendees on outcomes of resuscitation efforts: origins and impact on cardiopulmonary resuscitation preference.

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Previous studies have shown that individuals overestimate the success of cardiopulmonary resuscitation (CPR) while underestimating its morbidity. Although perceptions of CPR success affect medical care in the emergency department (ED), […]

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Early Treatment with Exosomes following Traumatic Brain Injury and Hemorrhagic Shock in a Swine Model Promotes Transcriptional Changes associated with Neuroprotection.

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We have shown that administration of mesenchymal stem cell (MSC)-derived exosomes (single dose given within 1 hour) in models of traumatic brain injury (TBI) and hemorrhagic shock (HS) is neuroprotective. […]

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Intravenous Cetirizine Versus Intravenous Diphenhydramine for the Treatment of Acute Urticaria: A Phase III Randomized Controlled Noninferiority Trial.

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Acute urticaria is a frequent presentation in emergency departments (EDs), urgent care centers, and other clinical arenas. Treatment options are limited if diphenhydramine is the only intravenous antihistamine offered because […]

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Trends in Diagnostic Point-of-Care Ultrasonography Reimbursement for Medicare Beneficiaries Among the US Emergency Medicine Workforce, 2012 to 2016.

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Point-of-care ultrasonography allows rapid diagnosis in the emergency department. A previous study found that a low prevalence of emergency medicine clinicians received point-of-care ultrasonography reimbursement in 2012 (0.7%). We determine […]

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Critical Care Delivery Solutions in the Emergency Department: Evolving Models in Caring for ICU Boarders.

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The National Academy of Medicine has identified emergency department (ED) crowding as a health care delivery problem. Because the ED is a portal of entry to the hospital, 25% of […]

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A Prospective Evaluation of Point-of-Care Ultrasonographic Diagnosis of Diverticulitis in the Emergency Department.

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We evaluate the sensitivity and specificity of point-of-care ultrasonography, performed by ultrasonographic fellowship-trained emergency physicians and physician assistants, compared with computed tomography (CT) scan in diagnosing acute diverticulitis in the […]

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Measuring ‘Need for Recovery’ as an indicator of staff well-being in the emergency department: a survey study.

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The Need for Recovery (NFR) Scale is an 11-item questionnaire that assesses how work affects intershift recovery. Items are summated to form a score with a maximum value of 100. […]

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What determines diagnostic resource consumption in emergency medicine: patients, physicians or context?

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A major cause for concern about increasing ED visits is that ED care is expensive. Recent research suggests that ED resource consumption is affected by patients’ health status, varies between […]

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Do Early Non-Steroidal Anti-Inflammatory Drugs for Analgesia Worsen Acute Kidney Injury in Critically Ill Trauma Patients? An Inverse Probability of Treatment Weighted Analysis.

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Administration of NSAIDs for acute post-traumatic analgesia is increasing in popularity as an alternative to opioids despite reservations regarding its potential impact on the development of acute kidney injury (AKI). […]

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Valproic Acid Decreases Resuscitation Requirements After Hemorrhage in a Prolonged Damage Control Resuscitation Model.

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Hemorrhage is the leading cause of preventable death in trauma. Future military conflicts are likely to be in austere environments, where prolonged damage control resuscitation (p-DCR) may be required for […]

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Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) for Thoracic Trauma in the Setting of Platelet Dysfunction: A Translational Swine Study.

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In patients with non-compressible torso hemorrhage (NCTH), antiplatelet medications may lead to worse outcomes. Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) may potentially stabilize these patients, but currently major […]

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Comparison of postoperative complications between open and laparoscopic appendectomy: An umbrella review of systematic reviews and meta-analyses.

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Laparoscopic appendectomy (LA) has been popular for decades because of shorter hospitalisation and return to routine activity. However, complications (e.g. surgical site infection (SSI) and intra-abdominal abscess (IAA)) relative to […]

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Biologic mesh implantation is associated with serious abdominal wall complications in patients undergoing emergency abdominal surgery – a randomized-controlled clinical trial.

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Open, emergency abdominal surgery is associated with a high incidence of fascial dehiscence and incisional hernia. Implantation of biologic meshes potentially reinforce the abdominal wall and therefore decrease such complications. […]

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The Neuroprotective Effect Of Quetiapine In Critically-Ill Traumatic Brain Injury Patients.

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Quetiapine is an atypical antipsychotic commonly used in critical care. Cellular and animal models demonstrated its novel anti-inflammatory properties in traumatic brain injury (TBI). Our study aimed to assess the […]

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Predictors of Retained Hemothorax in Trauma: Results of an EAST Multi-Institutional Trial.

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The natural history of traumatic hemothorax (HTX) remains unclear. We aimed to describe outcomes of HTX following tube thoracostomy drainage and to delineate factors that predict progression to a retained […]

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Colles’ type distal radial fractures undergoing manipulation in the ED: a multicentre observational cohort study.

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Colles’ type fractures of the distal radius are one of the most commonly manipulated fractures in the ED. Local audit data suggest that a high proportion of these injuries undergo […]

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I-FiBH trial: intravenous fluids in benign headaches-a randomised, single-blinded clinical trial.

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Many emergency physicians use an intravenous fluid bolus as part of a ‘cocktail’ of therapies for patients with headache, but it is unclear if this is beneficial. The objective of […]

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The efficacy of intravenous lidocaine and its side effects in comparison with intravenous morphine sulfate in patients admitted to the ED with right upper abdominal pain suspected of biliary colic.

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Intravenous (IV) Lidocaine can be used as analgesic in acute pain management in the emergency department (ED).Efficacy of IV Lidocaine in comparison with IV morphine in acute pain management in […]

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Outcome of Immediate Versus Early Antibiotics in Severe Sepsis and Septic Shock: A Systematic Review and Meta-analysis.

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Debate exists about the mortality benefit of administering antibiotics within either 1 or 3 hours of sepsis onset. We performed this meta-analysis to analyze the effect of immediate (0 to […]

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Prehospital Shock Precautions on Triage (PSPoT) score to assess in-hospital mortality for septic shock.

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In the prehospital setting, early identification of septic shock (SS) with high risk of poor outcome is a daily issue. There is a need for a simple tool aiming to […]

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