The European TREatment of ATopic eczema Taskforce (TREAT) Survey; prescribing practices in Europe for phototherapy and systemic therapy in moderate-to-severe adult atopic eczema patients.

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For many years dermatologists have had access to few therapies for patients with moderate-to-severe atopic eczema (AE). New promising therapies are entering the market but conventional phototherapies and systemic therapies […]

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Product of Investigator Global Assessment and body surface area (IGAxBSA): a practice-friendly alternative to the Eczema Area and Severity Index (EASI) to assess atopic dermatitis severity in children.

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Accurately documenting pediatric atopic dermatitis (AD) severity is important, but research tools, such as Eczema Area and Severity Index (EASI), are too time-consuming for clinical settings. Product of the Physician […]

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Measuring atopic eczema symptoms in clinical practice: The First Consensus Statement from the Harmonising Outcome Measures for Eczema in Clinical Practice Initiative.

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Measuring patient-centered outcomes in clinical practice is valuable for monitoring patients and advancing real-world research. A new initiative from the Harmonising Outcome Measures for Eczema (HOME) group aims to recommend […]

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The prevalence of and reasons for discontinuation of atopic eczema trials on ClinicalTrials.gov: a cross-sectional analysis.

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Research waste is a major issue in atopic eczema.1 One contributor is the premature discontinuation of trials. Although termination of trials is essential when participants are exposed to harm, many […]

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Clinicopathologic overlap of psoriasis, eczema, and psoriasiform dermatoses: A retrospective study of T helper type 2 and 17 subsets, interleukin 36, and β-defensin 2 in spongiotic psoriasiform dermatitis, sebopsoriasis, and tumor necrosis factor α inhibitor-associated dermatitis.

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T helper (Th) type 17 and Th2 cells mediate psoriasis and eczema, respectively. Some dermatoses exhibit overlapping clinicopathologic features, and their immunopathology is relatively unexplored.To determine whether Th17 and Th2 […]

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Early Life Exposure to Air Pollution and Incidence of Childhood Asthma, Allergic Rhinitis and Eczema.

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There is growing evidence that air pollution may contribute to the development of childhood asthma and other allergic diseases. In this follow-up of the Toronto Child Health Evaluation Questionnaire (T-CHEQ) […]

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Development and initial testing of a new instrument to measure the experience of eczema control in adults and children: Recap of atopic eczema (RECAP).

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Eczema control has been identified as an important outcome by key stakeholders in eczema research (including patients, carers, healthcare professionals, and researchers) but no validated instruments for the domain have […]

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Partner bereavement and risk of psoriasis and atopic eczema: cohort studies in the United Kingdom and Denmark.

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Stress is commonly cited as a risk factor for psoriasis and atopic eczema, but such evidence is limited.To investigate the association between partner bereavement (an extreme life stressor) and psoriasis […]

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Associations of eczema phenotypes with emotional and behavioural problems from birth until school age. The Generation R Study.

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Eczema phenotypes and emotional and behavioural problems are highly prevalent in childhood, but their mutual relationship is not fully clear.To examine the associations of eczema phenotypes with school-age emotional and […]

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The role of bacterial skin infections in atopic dermatitis: expert statement and review from the International Eczema Council Skin Infection Group.

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Patients with atopic dermatitis (AD) have an increased risk of bacterial skin infections that cause significant morbidity and, if untreated, may become systemic. Staphylococcus aureus (S. aureus) colonizes the skin […]

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Dupilumab in adolescents with uncontrolled moderate-to-severe atopic dermatitis: results from a phase IIa open-label trial and subsequent phase III open-label extension.

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Abstract: Dupilumab (monoclonal antibody inhibiting IL-4/IL-13 signalling) is approved for use in adolescents aged ? 12 years with inadequately controlled moderate-to-severe atopic dermatitis (AD). Dupilumab significantly improved AD signs/symptoms in […]

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A crosslinked polymer skin barrier film for moderate to severe atopic dermatitis: A pilot study in adults.

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Abstract: Occlusive treatments are a mainstay in atopic dermatitis (AD) management, but may not be well tolerated or lack compliance. A comfortable, semi-occlusive, artificial skin barrier that is well tolerated, […]

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Challenging a paradigm: Skin sensitivity to sodium lauryl sulfate is independent of atopic diathesis.

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Abstract: Sodium lauryl sulfate (SLS) is the best-studied detergent in irritant contact dermatitis. In atopic dermatitis, the two major pathophysiological abnormalities concern skin barrier function and regulation of cutaneous immune […]

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Validation of the Dutch Quality of Life in Hand Eczema Questionnaire (QOLHEQ).

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Abstract: Measurement instruments should be validated for use in the population in which they are intended to be used.To assess validity, reproducibility, responsiveness and interpretability of the Dutch version of […]

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Predictors of severe asthma attack re-attendance in Ecuadorian children: a cohort study.

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Abstract: Asthma is a common cause of emergency care attendance in low and middle-income countries (LMICs). While few prospective studies of predictors for emergency care attendance have been undertaken in […]

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Onchocerciasis (river blindness): larva-induced eczema (onchodermatitis) from an important oculocutaneous tropical disease spilling over into North America and Europe.

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Abstract: Onchocerciasis is a leading cause of blindness in the world. It may be seen in temperate climates of the United States and Europe in immigrants and travelers from endemic […]

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What’s new in atopic eczema? An analysis of systematic reviews published in 2017. Part 2: epidemiology, aetiology and risk factors.

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Abstract: This article forms part of a series of annual updates that summarizes the evidence base for atopic eczema (AE). It provides a summary of key findings from 28 systematic […]

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Skin diseases in rural Nyala, Sudan (in a rural hospital, in 12 orphanages, and in two refugee camps).

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Abstract: Skin diseases are considered to be common in Nyala, Sudan. This study was carried out to verify the prevalence of skin diseases in Nyala. This prospective observational study included […]

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Efficacy and safety of topical delgocitinib in patients with chronic hand eczema: data from a randomised, double-blind, vehicle-controlled Phase 2a study.

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Abstract: Management of chronic hand eczema (CHE) remains a challenge; effective topical treatment is still limited to corticosteroids.In this vehicle-controlled study, the efficacy/safety of a novel, pan-JAK inhibitor (delgocitinib) were […]

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Epidemiology and Risk Factors for Bacteremia in Pediatric and Adolescent Patients.

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Abstract: Epidemiology and risk factors for bacteremia in pediatric and adolescent patients have not been fully elucidated.The purpose of this study was to identify primary causative agents of bacteremia in […]

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TREatment of ATopic eczema (TREAT) Registry Taskforce: protocol for a European safety study of dupilumab and other systemic therapies in patients with atopic eczema.

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Abstract: A long-term prospective observational safety study is essential to fully characterize the safety profile of systemic immunomodulating therapies for patients with atopic eczema. The TREatment of ATopic eczema (TREAT) […]

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Higher self-reported severity of atopic dermatitis in adults is associated with poorer self-reported health-related quality of life in France, Germany, the UK and the US.

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Abstract: Better understanding of the relationship between atopic dermatitis (AD) severity and health-related quality of life (HRQoL) could help improve knowledge about the benefits of a more effective treatment of […]

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Allergic Diseases and Long Term Risk of Autoimmune Disorders: longitudinal cohort study and cluster analysis.

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Abstract: The association between allergic diseases (ADs) and autoimmune disorders (AIDs) is not well established.To determine incidence rates of AIDs in allergic rhinitis/conjunctivitis (ARC), atopic eczema (AE) and asthma, and […]

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What’s new in atopic eczema? An analysis of systematic reviews published in 2017. Part 1: treatment and prevention.

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Abstract: This review forms part of a series of annual updates that summarize the evidence base for atopic eczema (AE). It provides a summary of key findings from 25 systematic […]

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